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Liu Lab

The University of Texas at Austin College of Pharmacy

2018-2016

  1. Ushimaru, R.; Ruszczycky, M. W.; Chang, W.-C.; Yan, F.; Liu, Y.-n.; Liu, H.-w. “Substrate Conformation Correlates with the Outcome of Hyoscyamine 6β-Hydroxylase Catalyzed Oxidation Reactions.” J. Am. Chem. Soc. 2018, 140, 7433-7436. [NIHMSID 1020761]
  2. Huang, C.; Yang, C.; Zhang, W.; Zhang, L.; De, B.C.; Zhu, Y.; Jiang, X.; Fang, C.; Zhang, Q.; Yuan, C.-S.; Liu, H.-w.; Zhang, C.-s. “Molecular Basis of Dimer Formation During the Biosynthesis of Benzofluorene-Containing Atypical Angucyclines.” Nature Comm. 2018, 2088.
  3. Ruszczycky, M. W.; Zhong, A.; Liu, H.-w. “Following the Electrons: Peculiarities in the Catalytic Cycles of Radical SAM Enzymes.” Nat. Prod. Rep. 2018, 53, 615-621.
  4. Ko, Y.; Lin, G.-M.; Ruszczycky, M. W.; Liu, H.-w. “Mechanistic Implications of the Deamination of TDP-4-amino-4-deoxy-fucose Catalyzed by the Radical SAM Enzyme DesII.” Biochemistry 2018, 57, 3130-3133.
  5. Chen, J.-K.; Lin, W.-L.; Chen. Z.; Liu, H.-w. “PARP-1-Dependent Recruitment of Cold Induced RNA-Binding Protein Promotes Genome Stability.” Proc. Natl. Aca. Sci. USA. 2018, 115, E1759.
  6. Yang, Z.; Yang, S.; Yu, P.; Li, Y.; Doubleday, C.; Park, J.; Patel, A.; Jeon, B.-s.; Russell, W. K.; Liu, H.-w.; Russell, D. H.; Houk, K. N. “Influence of Water and Enzyme SpnF on the Dynamics and Energetics of the Ambimodal [6+4]/[4+2] Cycloaddition.” Proc. Natl. Aca. Sci. USA. 2018, 115, E848-E855.
  7. Besandre, R.; Liu, H.-w. “Biochemical Basis of Vosevi, a New Treatment for Hepatitis C.” Biochemistry 2018, 57, 479-480.
  8. Lin, G.-M.; Romo, A. J.; Liem, P. H.; Chen, Z.; Liu, H.-w. “Identification and Interrogation of the Herbicidin Biosynthetic Gene Cluster: First Insight into the Biosynthesis of a Rare Undecose Nucleoside Antibiotic.” J. Am. Chem. Soc. 2017, 139, 16450-16453.
  9. Kim, H. J.; Liu, Y.-n.; McCarty, R. M.; Liu, H.-w. “Biochemical Characterization and Stereochemical Analysis of Reactions Catalyzed by GenK, a Cobalamin-Dependent Radical SAM Methyltransferase Involved in Gentamicin Biosynthesis.” J. Am. Chem. Soc. 2017, 139, 16084-16087.
  10. Ruszczycky, M. W.; Liu, H.-w. “The Surprising History of an Antioxidant.” Nature 2017, 551, 37-38.
  11. Ruszczycky, M. W.; Liu, H.-w. “Theory and Application of the Relationship between Steady-State Isotope Effects on Enzyme Intermediate Concentrations and Net Rate Constants.” Meth. Enzymol. 2017, 596, 459-499.
  12. Jeon, B.-s.; Ruszczycky, M. W.; Russell, W. K.; Lin, G.-M.; Kim, N.; Choi, S.-h.; Wang, S-A.; Liu, Y.-n.; Patrick, J.; Russell, D. H.; Liu, H.-w. “Mechanistic Studies of the SpnF-Catalyzed [4+2]-Cycloaddition in the Biosynthesis of Spinosyn A.” Proc. Natl. Acad. Sci. USA 2017, 114, 10408-10413.
  13. Thibodeaux, C. J.; Liu, H.-w. “The Type II Isopentenyl Diphosphate: Dimethylallyl Diphos-phate Isomerase (IDI-2): A Model for Acid/Base Chemistry in Flavoenzyme Catalysis.” Arch. Biochem. Biophys. 2017, 632, 47-58.
  14. Zhang, Q.; Li, H.; Yu, L.; Sun, Y.; Zhu, Y.; Zhu, H.; Zhang, L.; Li, S.-M.; Shen, Y.; Tian, C.; Li, A.; Liu, H.-w.; Zhang, C. “Characterization of the Flavoenzyme XiaK as an N-Hydroxylase and Implications in Indolosesquiterpene Diversification.” Chem. Sci. 2017, 8, 5067-5077.
  15. Ko, Y.; Wang, S.-A.; Ogasawara, Y.; Ruszczycky, M. W.; Liu, H.-w. “Characterization of Enzyme-catalyzed Pyrazolopyrimidine Formation in the Biosynthesis of Formycin A.” Org. Lett. 2017, 19, 1426-1429.
  16. Jeon, B.-s.; Wang, S.-A.; Ruszczycky, M. W.; Liu, H.-w. “Natural [4+2]-Cyclases.” Chem. Review. 2017, 117, 5367-5388.
  17. Bridwell-Rabb, J.; Zhong, A.; Drennan, C. L.; Liu, H.-w. “A B12-dependent Radical SAM Enzyme Involved in Oxetanocin A Biosynthesis.” Nature 2017, 544, 322-326.
  18. Lin, C.-I.; McCarty, R. M.; Liu, H.-w. “Enzymology of Organic Transformations: A Survey of Name Reactions in Biological Systems.” Angew Chem. Int. Ed. 2017, 56, 3446-3489.
  19. Bridwell-Rabb, J.; Kang, G.; Zhong, A.; Liu, H.-w.; Drennan, C. L. “An HD-Domain Phosphohydrolase Active Site Tailored for Oxetanocin-A Biosynthesis.” Proc. Natl. Acad. Sci. USA. 2016, 113, 13750-13755.
  20. Lin, G.-M.; Sun, H. G.; Liu, H.-w. “Study of the Uridine 5’-Monophosphate (UDP)-Galactopyranose Mutase Using UDP-5-Fluoro-Galactopyransoe As a Probe: Incubation Results and Mechanistic Implications.” Org. Lett. 2016, 18, 3438-3441.
  21. Ushimaru, R.; Lin, C.-I.; Sasaki, E.; Liu, H.-w. “Characterization of Enzymes Catalyzing Transformations of Cysteine S-Conjugated Intermediates in the Lincosamide Biosynthesis Pathway.” ChemBioChem 2016, 17, 1606-1611.
  22. Patel, A.; Chen, Z.; Yang, Z.; Gutierrez, O.; Houk, K. N.; Liu, H.-w.; Singleton, D. A. “Dynamically Complex Enzyme-catalyzed [6+4] and [4+2] Cycloadditions in the Biosyn-thesis of Spinosyn A.” J. Am. Chem. Soc. 2016, 138, 3631-3634.
  23. He, W.; Liu, M.; Li X.; Zhang, X.; Abdel-Mageed, W. M.; Li L.; Wang, W.; Zhang, J.; Han, J.; Dai, H.; Quinn, R. J.; Liu, H.-w.; Luo, H.; Liu, X.; Zhang, L. “Fungal Biotransformation of Tanshinone Results in [4+2] Cycloaddition with Sorbicillinol: Evidence for Enzyme Catalysis and Increased Antibacterial Activity.” Appl. Microbiol. Biotechnol. 2016, 100, 8349-8357.
  24. Jackson, D. R.; Yu, X.; Wang, G.; Calveras, J.; Patel, A. B.; Calveras, J.; Barajas, J. F.; Sasaki, E.; Metsä-Ketelä, M.; Liu, H.-w.; Rohr, J.; Tsai, S.-C. “Insights Into Complex Oxidation During BE-7585A Biosynthesis: Structural Determination and Analysis of the Polyketide Monooxygenase BexE.” ACS Chem. Biol. 2016, 11, 1137-1147
  25. Kim, H. J.; LeVieux, J.; Yeh, Y.-C.; Liu, H.-w. “C3′-Deoxygenation of Paromamine Catalyzed by a Radical SAM Enzyme: Characterization of AprD4 and Its Reductase Partner AprD3.” Angew. Chem. Int. Ed. 2016, 55, 3724-3728.