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Liu Lab

The University of Texas at Austin College of Pharmacy

2015-2013

  1. Caldara-Festin, G. F.; Jackson, D. R.; Barajas, J. F.; Valentic, T. R.; Patel, A.; Aguilar, S.; Nguyen, M.; Vo, M.; Khanna, A.; Sasaki, E.; Liu, H.-w.; Tsai, S.-C. “The Structural and Functional Analysis of Two Di-Domain Aromatases/Cyclases from Type II Polyketide Synthases.” Proc. Natl. Acad. Sci. USA 2015, 112, E6844-6851.
  2. Liu, C.-H.; Wang, S.-A.; Ruszczycky, M. W.; Chen, H.; Li, K.; Murakami, K.; Liu, H.-w. “Studies of 1-Amino-2,2-difluorocyclopropane-1-carboxylate: Mechanism of Decomposition and Inhibition of ACC Deaminase.” Org. Lett. 2015, 17, 3342-3345.
  3. Lin, G.-m.; Choi, S.-h.; Ruszczycky, M. W.; Liu, H.-w. “Mechanistic Investigation of the Radical S-Adenosyl-methionine Enzyme DesII Using Fluorinated Analogs.” J. Am. Chem. Soc. 2015, 137, 4964-4967.
  4. Ruszczycky, M. W.; Liu, H.-w. “Mechanistic Enzymology of the Radical SAM Enzyme DesII.” Israel. J. Chem. 2015, 55, 315-324.
  5. Hashimoto, T.; Hashimoto, J.; Teruya, K.; Hirano, T.; Shin-ya, K.; Ikeda, H.; Liu, H.-w.; Nishiyama, M.; Kuzuyama, T. “Biosynthesis of Versipelostatin: Identification of an Enzyme-catalyzed [4+2]-Cycloaddition Required for Macrocyclization of Spirotetronate-Containing Polyketides.” J. Am. Chem. Soc. 2015, 137, 572-575.
  6. Fage, C.; Isiorho, E. A.; Liu, Y.-n.; Dew, T. W.; Liu, H.-w.; Keatinge-Clay, A. T. “The 1.50 A Resolution Structure of SpnF – A Standalone Enzyme Catalyzing [4+2]-Cycloaddition in Spinosyn Biosynthesis.” Nature Chem. Biol. 2015, 11, 256-260.
  7. Ko, Y.; Ruszczycky, M. W.; Liu, H.-w. “Mechanistic Studies of the Radical SAM Enzyme DesII with TDP-D-fucose.” Angew. Chem. Int. Ed. 2015, 54, 860-863.
  8. Kim, H. J.; Choi, S.-h.; Pongdee, R.; Jeon, B.-s.; Kim, N.; Wu, Q.; Liu, H.-w. “Chemoenzymatic Synthesis of Spinosyn A.” Angew. Chem. Int. Ed. 2014, 53, 13553-13557.
  9. Isiorho, E. A.; Jeon, B.-S.; Liu, H.-w.; Keatinge-Clay, A. T. “Structure Studies of SpnP: A Glycosyltransferase Catalyzing Forosaminylation in Spinosyn Biosynthesis.” Biochemistry 2014, 53, 4292-4301.
  10. Shen, L.; Wang, Y.; Lin, C.-I.; Liu, Y.-n.; Liu, H.-w.; Guo, A.; Zhu, X.-Y. “Membrane Environment Can Enhance the Binding of Influenza A Virus Hemagglutinin to Cell Surface Glycan Receptors.” ACS Chem. Biol. 2014, 9, 1877-1884.
  11. Mansoorabadi, S. O.; Tao, Z.; Wu, M.; Gao, P.; Pingali, S. V.; Guo, L.; Liu, H.-w. “Conformational Activation of Poly(ADP-ribose) Polymerase-1 Upon DNA Binding Revealed by Small-Angle X-ray Scattering.”Biochemistry 2014, 53, 1779-1788.
  12. Huang, H.; Chang, W.-c.; Lin, G.-m.; Romo, A.; Pai, P.-J.; Russell, D. H.; Liu, H.-w. “Mechanistic Consequences of Chiral Radical Clock Probes: Analysis of the Mononuclear Non-Heme Iron Enzyme HppE with 2-Hydroxy-3-methylenecyclopropyl Radical Clock Substrates.” J. Am. Chem. Soc. 2014, 136, 2944-2947.
  13. Sasaki, E.; Zhang, X.; Sun, H. G.; Lu, M.-Y. J.; Liu, T.-l.; Ou, A.; Li, J.-y.; Chen. Y-h.; Ealick, S. E.; Liu, H.-w. “Exploiting Sulfur Carrier Proteins from Primary Metabolism for 2-Thiosugar Biosynthesis.” Nature 2014,510, 427-431.
  14. Cammarata, M.; Lin, K.-Y.; Pruet, J.; Liu, H.-w.; Brodbelt, J. “Probing the Unfolding of Myoglobin and Domain C of PARP-1 with Covalent Labeling and Top-Down 193 nm Ultraviolet Photodissociation Mass Spectrometry.” Anal. Chem. 2014, 86, 2534-2542.
  15. Lin, C.-I.; Sasaki, E.; Zhong, A.; Liu, H.-w. “In Vitro Characterization of LmbK and LmbO: Identification of GDP-D-erythro-α-D-gluco-octose as a Key Intermediate in Lincomycin A Biosynthesis.” J. Am. Chem. Soc.2014, 136, 906-909.
  16. Wang, C.; Chang, W.-c.; Guo, Y.; Huang, H.; Peck, S.; Pandelia, M. E.; Lin, G.-m.; Liu, H.-w.; Krebs, C.; Bollinger, J. M., Jr. “Evidence that the Fosfomycin-producing Expoxidase, HppE, is a Novel Non-heme-iron Peroxidase.” Science 2013, 342, 991-995.
  17. Al-Mestarihi, A.; Romo, A. R.; Liu, H.-w.; Bachmann, B. O. “Nitrososynthase Triggered Oxidative Carbon-Carbon Bond Cleavage in Baumycin Biosynthesis.” J. Am. Chem. Soc. 2013, 135, 11457-11460.
  18. Chang, W.-c.; Mansoorabadi, S. O.; Liu, H.-w. “The Reaction of HppE with Substrate Analogues: Evidence for Carbon-Phosphorus Bond Cleavage by a Carbocation Rearrangement. ” J. Am. Chem. Soc. 2013, 135, 8153-8156.
  19. Kim, H. J.; McCarty, R. M.; Ogasawara, Y.; Mansoorabadi, S. O.; Liu, Y.-n.; Levieux, J.; Liu, H.-w. “The GenK-catalyzed C-6′ Methylation in the Biosynthesis of Gentamicin: Isolation and Characterization of a Cobalamin-dependent Radical SAM Enzyme.” J. Am. Chem. Soc. 2013, 135, 8093-8096.
  20. Chang, W-.c.; Song, H.; Liu, H.-w.; Liu, P. “Current Development in Isoprenoid Precursor Biosynthesis and Regulation.” Curr. Opin Chem. Biol. 2013, 17, 571-579.
  21. Liu, H.-w.; Begley, T. “Natural Product Biosynthesis – a Renaissance.” Curr. Opin Chem. Biol. 2013, 17, 529-531.
  22. Zhao, L.; Chang, W-.c.; Xiao, Y.; Liu, H.-w.; Liu, P. “Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis.” Annu. Rev. Biochem. 2013, 82, 497-503.
  23. Chang, W-.c.; Dey, M.; Liu, P.; Mansoorabadi, S. O.; Moon, S.-J.; Zhao, Z. K.; Drennan, C. L.; Liu, H.-w. “Mechanistic Studies of an Enzymatic Unprecedented 1,2-Phosphono Migration Reaction.” Nature 2013, 496, 114-118.
  24. Lin, C.-I.; McCarty, R. M.; Liu, H.-w. “The Biosynthesis of Nitrogen- Sulfur-, and Higher-carbon Chain Containing Sugars.” Chem. Soc. Rev. 2013, 42, 4377-4407.
  25. Ruszczycky, M. W.; Choi, S. H.; Liu, H.-w. “A Combined EPR-Kinetic Isotope Effect Study of Radical-Mediated Dehydrogenation of an Alcohol by the Radical SAM Enzyme DesII: Evidence for General Base Catalysis. ” Proc. Natl. Acad. Sci. USA 2013, 110, 2088-2093.
  26. Liu, H.-w.; Thibodeaux, C. J.; Calveras, J.; Chang, W.-c. “Determining the Role of the Reduced FMN Coenzyme in the Reaction Catalyzed by the Type II Isopentenyl Diphosphate:Dimethylally Diphosphate Isomerase (IDI-2).” In Proceedings of the 17th International Symposium of Flavins and Flavoproteins. Miller, S., Hille, R., Palfey, B., Cecchini, G. Eds.; Alan R. Liss: New York, 2013, 21-32.