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Liu Lab

The University of Texas at Austin College of Pharmacy

1997-1995

  1. Sheldon, P. J.; Johnson, D. A.; August, P. R.; Liu, H.-w.; Sherman, D. H. “Cellular Self-Protection Against the Antitumor Antibiotic Mitomycin in Streptomyces lavendulae,” In Industrial Microorganisms: Basic and Applied Molecular Genetics, Baltz, R., Hegemann, G., Skatrud, P. Eds; 1997, Vol. 34, p 123-130.
  2. Dakoji, S.; Shin, I.; Battaile, K. P.; Vockley, J.; Liu, H-w. “Redesigning the Active Site of Acyl-CoA Dehydrogenase: New Evidence Supporting a One-base Mechanism,” Bioorg. Med. Chem. 1997, 5, 2157-2164.
  3. Sheldon, P. J.; Johnson, D. A.; August, P. R.; Liu, H.-w.; Sherman, D. H. “Characterization of a Mitomycin Resistance Determinant (mrd) from the Producing Organism, Streptomyces lavendulae,” J. Bacteriol. 1997,179, 1796-1804.
  4. Johnson, D. A.; August, P. R.; Shackleton, C.; Liu, H.-w.; Sherman, D. H. “Microbial Resistance to Mitomycins Involves a Redox Relay Mechanism,” J. Am. Chem. Soc. 1997, 119, 2576-2677.
  5. Pieper, P. A.; Yang, D.-y.; Zhou, H.-q.; Liu, H.-w. “3-Deoxy-3-fluoropyridoxamine 5′-Phosphate: The Synthesis, Chemical and Biological Properties of a Coenzyme B6 Analog,” J. Am. Chem. Soc. 1997, 119, 1809-1817.
  6. Ballou, D. P.; Gassner, G. T.; Johnson, D. A.; Liu, H.-w.; Bandarian, V.; Ruzicka, F.; Reed, G. H. “Kinetics of Formation of an Organic Radical in the Ascarylose Biosynthesis by a Protein Complex Containing FAD, B,6, and Two [2Fe-2S] Centers,” In Flavins and Flavoproteins; Stevenson, K. J.; Massey, V.; Williams, C. H., Jr.; Eds.; University of Calgary Press: Calgary, 1997,889-898.
  7. He, X.; Ploux, O.; Liu, H.-w. “Biosynthesis of 3,6-Dideoxyhexoses: In Vivo and In Vitro Evidence for Protein-Protein Interaction Between CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase (E1) and Its Reductase (E3),” Biochemistry 1996, 35, 16412-16420.
  8. Johnson, D. A.; Gassner, G. T.; Bandarian, V.; Ruzicka, F.; Ballou, D. P.; Reed, G. H.; Liu, H.-w.; “Kinetic Characterization of an Organic Radical in the Ascarylose Biosynthetic Pathway,” Biochemistry1996, 35, 15846-15857.
  9. Dakoji, S.; Shin, I.; Becker, D. T.; Stankovich, M. T.; Liu, H.-w. “Studies of Acyl-CoA Dehydrogenase Catalyzed Allylic Isomerization: A One-base or Two-base Mechanism?,” J. Am. Chem. Soc. 1996, 118, 10971-10979.
  10. Li, K.; Du, W.; Que, N. L. S.; Liu, H.-w. “Mechanistic Studies of 1-Aminocyclopropane-1-carboxylate Deaminase: Unique Covalent Catalysis by Coenzyme B6,” J. Am. Chem. Soc. 1996, 118, 8763-8764.
  11. Burns, K. D.; Pieper, P. A.; Liu, H.-w.; Stankovich, M. T. “Characterization of the Spectral and Thermodynamic Properties of CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase Reductase (E3) and CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase (E1),” Biochemistry, 1996, 35, 7879-7889.
  12. Gassner, G. T.; Johnson, D. A.; Liu, H.-w.; Ballou, D. P. “Kinetics of the Reductive Half Reaction of the Iron-Sulfur Flavoenzyme CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase Reductase,” Biochemistry,1996, 35, 7752-7761.
  13. He, X.; Thorson, J. S.; Liu, H.-w. “Probing the Coenzyme and Substrate Binding Events of CDP-D-glucose 4,6-Dehydratase: Mechanistic Implications,” Biochemistry, 1996, 35, 4721-4731.
  14. Li, D.; Guo, Z.; Liu, H.-w. “Mechanistic Studies of the Inactivation of Crotonase by (Methylenecyclopropyl)formyl-CoA,” J. Am. Chem. Soc. 1996, 118, 275-276.
  15. Liu, H.-w.; Thorson, J. S.; Miller, V. P.; Kelley, T. M.; Lei, Y.; Ploux, O.; He, X.; Yang, D.-y. “Mechanistic Studies of the Biosynthesis of 3,6-Dideoxysugars in Bacteria: Exploration of a Novel C-O Bond Cleavage Event,” J. Chin. Chem. Soc. 1995, 42, 627-636.
  16. Piper, P. A.; Guo, Z.; Liu, H.-w. “Mechanistic Studies of 3,6-Dideoxysugar Biosynthesis: Stereochemical Course of C-3 Deoxygenation,” J. Am. Chem. Soc. 1995, 117, 5158-5159.
  17. Lei, Y.; Ploux, O.; Liu, H.-w. “Mechanistic Studies of CDP-6-deoxy-D-glycero-L-threo-4-hexulose-3-dehydrase: Identification of His220 as the Active-site Base by Chemical Modification and Site-directed Mutagenesis,” Biochemistry 1995, 34, 4643-4654.
  18. Ploux, O.; Lei, Y.; Vatanen, K.; Liu, H.-w. “Mechanistic Studies on CDP-6-deoxy-Δ3,4-glucoseen Reductase: the Role of Cysteine Residues in Catalysis as Probed by Chemical Modification and Site Directed Mutagenesis,” Biochemistry 1995, 34, 4159-4168.