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Liu Lab

The University of Texas at Austin College of Pharmacy

1994-1991

  1. Taoka, S.; Padmakumar, R.; Lai, M.-t.; Liu, H.-w.; Banerjee, R. “Purification and Inhibition of Human Methylmalonyl-CoA Mutase,” J. Biol. Chem. 1994, 269, 31630-31634.
  2. Johnson, C. C.; Lai, M.-t.; Liu, H.-w.; Matin-Esker, A. A.; Newcomb, M.; Oh, E. ” Highly Regioselective and Rapid Ring Opening of the (Methylcyclopropyl)methyl Radical,” Bioorg. Med. Chem. Lett. 1994, 4, 2693-2696.
  3. Shin, I.; Li, D.; Becker, D. T.; Stankovich, M. T.; Liu, H.-w. “Cyclobutaneacetyl-CoA, A Janus-faced Substrates for Acyl-CoA Dehydrogenases,” J. Am. Chem. Soc. 1994, 116, 8843-8844.
  4. Liu, H.-w.; Thorson, J. S. “Pathways and Mechanisms in the Biogenesis of Novel Deoxy Sugars by Bacteria,“Annu. Rev. Microbiol. 1994, 48, 223-256.
  5. Thorson, J. S.; Lo, S. F.; Ploux, O.; He, X.; Liu, H.-w. “Studies of the Biosynthesis of 3,6-Dideoxyhexoses inYersinia pseudotuberculosis: Molecular Cloning and Characterization of the asc (ascarylose) Region fromYersinia pseudotuberculosis serogroup VA,” J. Bacteriol. 1994, 176, 5483-5493.
  6. Swedenborg, P. D.; Jones, R. L.; Shin, I.; Zhou, H.-q.; Liu, H.-w. “Biological Activity of (SRS)-3,5-Dimethyl-6-(methylethyl)-3,4,5,6-tetrahydropyran-2-one, a Sex Pheromone for Macrocentrus grandii (Goidanich) (Hymenoptera: Braconidae),” J. Chem. Ecology, 1994, 20, 3373-3380.
  7. Thorson, J. S.; Kelly, T. M.; Liu, H.-w. “Cloning, Sequencing, and Overexpression in Escherichia coli of the α-D-Glucose-1-Phosphate Cytidylyltransferase Gene Isolated from Yersinia pseudotuberculosis,” J. Bacteriol.1994, 176, 1840-1849.
  8. Lo, S. F.; Miller, V. P.; Lei, Y.; Thorson, J. S.; Liu, H.-w.; Schottel, J. L. “CDP-6-deoxy-Δ3,4-glucoseen Reductase from Yersinia pseudotuberculosis: Enzyme Purification and Characterization of the Cloned Gene,“J. Bacteriol. 1994, 176, 460-468.
  9. Thorson, J. S.; Liu, H.-w. “Coenzyme B6 as a Redox Cofactor – A New Role for an Old Coenzyme?,” J. Am. Chem. Soc. 1993, 115, 12177-12178.
  10. Miller, V. P.; Thorson, J. S.; Lo, S. F.; Ploux, O.; Liu, H.-w. “Cofactor Characterization and Mechanistic Studies of CDP-6-deoxy-Δ3,4-glucoseen Reductase: Exploration into a Novel Enzymatic C-O Bond Cleavage Event,” Biochemistry 1993, 32, 11934-11942.
  11. Thorson, J. S.; Liu, H.-w. “Characterization of the First PMP Dependent Iron-Sulfur Containing Enzyme Which is Essential for the Biosynthesis of 3,6-Dideoxyhexoses,” J. Am. Chem. Soc. 1993, 115, 7539-7540.
  12. Thorson, J. S.; Lo, S. F.; Liu, H.-w.; Hutchinson, C. R. “Studies of the Biosynthesis of 3,6-Dideoxyhexoses: New Mechanistic Implications Relevant to 2,6-Dideoxy, 4,6-Dideoxy, and Amino Sugar Construction,” J. Am. Chem. Soc. 1993, 115, 6993-6994.
  13. Thorson, J. S.; Lo, S. F.; Liu, H.-w. “Molecular Basis of 3,6-Dideoxyhexose Biosynthesis: Elucidation of CDP-ascarylose Biosynthetic Genes and Their Relationship to Other 3,6-Dideoxyhexose Pathways,” J. Am. Chem. Soc. 1993, 115, 5827-5828.
  14. Shin, I.; Zhou, H.-q.; Que, N. L.; Liu, H.-w. “A Sex Pheromone Isolated from Macrocentrus grandii: Absolute Stereochemistry Determination and Implications,” J. Org. Chem. 1993, 58, 2923-2926.
  15. Lai, M.-t.; Li, D.; Oh, E.; Liu, H.-w. “Inactivation of Medium-chain Acyl-CoA Dehydrogenase by a Metabolite of Hypoglycin: Characterization of the Major Turnover Product and Evidence Suggesting an Alternative Flavin Modification Pathway,” J. Am. Chem. Soc. 1993, 115, 1619-1628.
  16. Swedenborg, P. D.; Jones, R. L.; Liu, H.-w.; Krick, T. P. “(3R*,5S*,6R*) – 3,5 – Dimethyl – 6 – (methylethyl) – 3,4,5,6 – tetrahydropyran – 2 – one, a Third Sex Pheromone Component for Macrocentrus grandii (Goidanich) (Hymenoptera:braconidae),” J. Chem. Ecology 1993, 19, 485-502.
  17. Lai, M.-t.; Oh, E.; Liu, H.-w. “Studies of the Inactivation of General Acyl-CoA Dehydrogenase: Inhibition Studies and Stereospecific Synthesis of (Methylenecyclopropyl)acetyl-CoA,” Bioorg. Med. Chem. Lett. 1992,2, 1423-1426.
  18. Thorson, J. S.; Oh, E.; Liu, H.-w. “Studies of Complex Enzymatic Pyridine Nucleotide-Dependent Transformations: Structure and Cofactor Binding Correlation in CDP-D-glucose Oxidoreductase,” J. Am. Chem. Soc. 1992, 114, 6941-6942.
  19. Lai, M.-t.; Liu, H.-w. “New Evidence Supporting a Radical Mechanism of the Inactivation of General Acyl-CoA Dehydrogenase by a Metabolite of Hypoglycin,” J. Am. Chem. Soc. 1992, 114, 3160-3162.
  20. Yu, Y.; Russell, R. N.; Liu, L.-d.; Thorson, J. S.; Liu, H.-w. “Mechanistic Studies of the Biosynthesis of 3,6-Dideoxyhexoses in Yersinia pseudotuberculosis: Purification and Stereochemical Analysis of CDP-D-glucose Oxidoreductase,” J. Biol. Chem. 1992, 267, 5868-5875.
  21. Lai, M.-t.; Oh, E.; Shih, Y.; Liu, H.-w. “Stereospecific Synthesis of (Methylenecyclopropane)acetyl-CoA, the Causative Agent of Jamaican Vomiting Sickness,” J. Org. Chem. 1992, 57, 2471-2476.
  22. Weigel, T. M.; Miller, V. P.; Liu, H.-w. “Mechanistic and Stereochemical Studies of an Unique Dehydration Catalyzed by CDP-4-keto-6-deoxy-D-glucose-3-dehydrase, a Pyridoxamine 5′-Phosphate Dependent Catalyst Isolated from Yersinia pseudotuberculosis,” Biochemistry 1992, 31, 2140-2147.
  23. Weigel, T. M.; Liu, L.-d.; Liu, H.-w. “Mechanistic Studies of the Biosynthesis of 3,6-Dideoxyhexoses inYersinia pseudotuberculosis: Purification and Characterization of CDP-4-keto-6-deoxy-D-glucose-3-dehydrase,” Biochemistry 1992, 31, 2129-2139.
  24. Miller, V. P.; Liu, H.-w. “Biosynthesis of 3,6-Dideoxy Hexoses: New Evidence Supporting a Radical Mechanism for C-3 Deoxygenation,” J. Am. Chem. Soc. 1992, 114, 1880-1881.
  25. Russell, R. N.; Liu, H.-w. “Stereochemical and Mechanistic Studies of CDP-D-glucose Oxidoreductase Isolated from Yersinia pseudotuberculosis,” J. Am. Chem. Soc. 1991, 113, 7777-7778.
  26. Lai, M.-t.; Liu, L.-d.; Liu, H-w. “Mechanistic Study of the Inactivation of General Acyl-CoA Dehydrogenase by a Metabolite of Hypoglycin A,” J. Am. Chem. Soc. 1991, 113, 7388-7397.
  27. Yang, D.-y.; Shih, Y.; Liu, H.-w. “Chemical Synthesis of stereospecifically Labeled Pyridoxamine-5′-phosphate,” J. Org. Chem. 1991, 56, 2940-2946.

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