UT Shield

2027-2025

  1. Ren, D.; Zhou, T.-P.; Xiong, J.; Hou, X.; Lee, Y.-H.; Zhou, J.; Guo, Y.; Wang, B.; Liu, H.-w. “Decyanation, Dioxygenation and Oxidative Ring Contraction Catalyzed by the DUF4243 Oxidase OzmD Relies on Ferric Oxygen Activation.” in revision.
  2. Ren, D.; Lee, Y.-H.; Liu, H.-w. “Revised Biosynthetic Pathway of Alnumycin Involves a Complex Interplay of Redox Reactions, Stereoisomerization and an Atypical DUF6081 Isomerase.” in revision.
  3. Zhao, H.; Bu, J.; Liu, H.-w. “Characterization of an Unusual Suicide Radical AdoMet Enzyme MybB Catalyzing Sulfur Incorporation into the Biosynthesis of Antitubercular Mycobacidin.” Meth. Enzymol. in press.
  4. Kim, W.; Hong, Y.; Sato, S.; Liu, H.-w.; Zhang, Y. J. “Structural and Mechanistic Basis of 4′-Dehydrogenation Catalyzed by AprD5 in Apramycin Biosynthesis.” Biochemistry 2026, 65, in press.
  5. Ren, D.; Lee, Y.-H.; Liu, H.-w. “C-Glycosylation as the Organizing Principles in C-Nucleosides Biosynthesis.” Acc. Chem. Res. 2026, 59, in press.
  6. Kuo, Y.-A.; Chen, Y. I.; Siraj, N.; He, Y.; Yang, Z.; Wang, Y.; Batchelder-Schwab, E. J.; Korkmaz, Z.; Yonas, S.; Nguyen, T. D.; Hong, S.; Nguyen, A.-T.; Kim, S.; Seifi, S.; Fan, P.-H.; Wu, Y.; Liu, H.-w.; Lu, Y.; Ren, P.; Mao, C.; Yeh, H.-C. “Fluorogenic Aptamer Optimization on a Massively Parallel Sequencing Platform.” ACS Sens, 2026, 11, 3587-3600.
  7. Zhao, H.; Liu, H.-w. “A Novel Amidation Reaction Couples the Siderophore Bait with the SB-217452 Warhead to Complete the Biosynthesis of the Trojan-horse Antibiotic Albomycin δ2.” J. Am. Chem. Soc. 2026, 148, 21797-21806.
  8. Y.-H.; Liu, H.-w. “tRNA‑deacylases as Beacons for Noncanonical Amino Acid Biosynthesis.” Nature Chem. 2026, 18, 815-816. [PMID: 42014785]
  9. Lee, Y.-H.; Zheng, Z.; Ma, B.; Ren, D.; Ruszczycky, M. W.; Tao, L.; Liu, H.-w. “The Radical SAM Enzyme BlsE Can Operate as a Dehydratase, Dehydrogenase or Epimerase Upon Mutation of a Single Active Site Serine Residue.” J. Am. Chem. Soc. 2026, 148, 7093-7101. [PMC13003564]
  10. Ushimaru, R.; Chen, R.; Fan, P.-H.; Liu, X.; Ruszczycky, M. W.; Liu, H.-w. “Refining the Substrate-Cofactor Disposition Model of H6H Catalysis Using Hyoscyamine Analogs.” J. Am. Chem. Soc. 2025, 147, 46543-46549.
  11. Zheng, Z.; Lee, Y.-H.; Liu, H.-w. “A Selenium-for-Oxygen Swapping Reaction Catalyzed by the Radical S-Adenosyl Methionine Enzyme AbmM.” J. Am. Chem. Soc. 2025, 147, 41256-41260.
  12. Zheng, Z.; Lee, Y.-H.; Ren, D.; Liu, H.-w. “Pyrazofurin Biosynthesis Involves Nonenzymatic Contraction of a Pyridazine Intermediate Triggered by A Rieske Enzyme Catalyzed Oxygenation.” J. Am. Chem. Soc. 2025, 147, 42070-42075.
  13. Zhao, H.; Chen, Z.; Franklin, J. L.; Liu, H.-w. “Characterization of C3′ Epimerization of the Thioheptose Core in the Biosynthesis of Albomycin δ2 Catalyzed by the Radical S-Adenosylmethionine Enzyme AbmJ.” ACS Catal. 2025, 15, 18104-18111.
  14. Zheng, Z.; Ushimaru, R.; Mori, T.; Ruszczycky, M. W.; Abe, I.; Liu, H.-w. “Biosynthesis of the Thiofuranose Core in Albomycin Requires a Versatile Enzyme AbmG That Catalyzes Net Dehydration via Cryptic Phosphorylation.” J. Am. Chem. Soc. 2025, 147, 34143-34149.
  15. Zheng, Z.; Ushimaru, R.; Thomas, C. M.; Liu, H.-w. “Radical Propagation via σ-Cleavage Mediates Radical SAM Catalyzed Sulfur-for-Oxygen Swapping Reaction during the Biosynthesis of Albomycin δ2.” J. Am. Chem. Soc. 2025, 147, 32118-32123. [PMC12401566]
  16. Kim, W.; Fan, P.-h.; Bu, J.; Liu, H.-w.; Zhang, Y. J. “Structural-guided Mechanistic Investigation of Stereochemical Inversion During the Octose Formation Catalyzed by an Atypical Transaldolase AprG in the Biosynthesis of Apramycin.” ACS Catal. 2025, 15, 13778-13786. [PMC12377196]
  17. Lee, Y.-H.; Fan, P.-H.; Yeh, Y.-C.; Ruszczycky, M. W.; Geng, Y.; Zhong, A.; Liu, H.-w. “A [2.1.0]-Fused Bicyclic Intermediate is Produced during the Biosynthesis of Oxetane Nucleosides.” J. Am. Chem. Soc. 2025, 147, 25224-25232. [PMC12379298]
  18. Ushimaru, R.; Zheng, Z.; Xiong, J.; Mori, T.; Guo, Y.; Abe, I.; Liu, H.-w. “Radical SAM FeS-cluster Implicated as the Sulfur Donor during Albomycin Biosynthesis.” Nature Catal. 2025, 8, 760-770. [PMC12372959]
  19. Ren, D.; Lee, Y.-H.; Liu, H.-w. “Reinvestigation of the C-Glycoside Synthase in Alnumycin Biosynthesis Reveals a Conserved Mechanism of C–C Bond Formation.” J. Am. Chem. Soc. 2025, 147, 20571-20581. [PMC12228513]
  20. Kim, W.; Zheng, Z.; Kim, K.; Lee, Y.-H.; Liu, H.-w.; Zhang, Y. J. “Structural and Mechanistic Insights into KslB, a Bacterial Pictet-Spenglerase in Kitasetaline Biosynthesis.” RCS Chem Biol. 2025, 6, 933-941. [PMC12012969]
  21. Zheng, Z.; Ren, D.; Ko, Y.; Liu, H.-w. “Revision of the Formycin A and Pyrazofurin Biosynthetic Pathways Reveals Specificity for d-Glutamic Acid and a Cryptic N-Acylation Step During Pyrazole Core Formation.” J. Am. Chem. Soc. 2025, 147, 11425-11431. [PMC11964824]
  22. Lee, Y-H.; Ren, D.; Chen. R.; Liu, X.; Engstrom, A.; Liu, H.-w. “Blasticidin S Biosynthesis Involves a Unique Interplay between a Radical SAM Dehydratase, a Transaminase and an ATP-Grasp Ligase in Order to Avoid a Futile Cycle.” ACS Catalysis, 2025, 15, 2742-2749. [PMC12352542]
  23. Ma, B.; Lee, Y.-H.; Ruszczycky, M. W.; Ren, D.; Engstrom, A.; Liu, H.-w.; Tao, L. “EPR Characterization of the BlsE Substrate Radical Offers Insight into the Determinants of Reaction Outcome that Distinguish Radical SAM Dioldehydratases from Dehydrogenases.” J. Am. Chem. Soc. 2025, 147, 4111-4119. [PMC11826333]
  24. Zhao, H.; Bu, J.; Liu, H.-w. “Radical S-Adenosylmethionine Sulfurtransferase MybB Catalyzed Formation of the 4-Thiazolidinone Core in Mycobacidin Represents an Intersection between Primary and Secondary Metabolism.” J. Am. Chem. Soc. 2025, 147, 4180-4187. [PMC11826332]
  25. Zheng, Z.; Ren, D.; Ko, Y.; Liu, H.-w. “Revision of the Formycin A and Pyrazofurin Biosynthetic Pathways Reveals Specificity for D-Glutamic Acid and a Cryptic N-Acylation During Pyrazole Core Formation.” J. Am. Chem. Soc. 2025, 147, 11425-11431. [NIHMSID2067859]
  26. Lee, Y-H.; Ren, D.; Chen. R.; Liu, X.; Engstrom, A.; Liu, H.-w. “Blasticidin S Biosynthesis Involves a Unique Interplay between a Radical SAM Dehydratase, a Transaminase and an ATP-Grasp Ligase in Order to Avoid a Futile Cycle.” ACS Catalysis 2025, 15, 2742-2749. [NIHMSID2055467]
  27. Ma, B.; Lee, Y.-H.; Ruszczycky, M. W.; Ren, D.; Engstrom, A.; Liu, H.-w.; Tao, L. “EPR Characterization of the BlsE Substrate Radical Offers Insight into the Determinants of Reaction Outcome that Distinguish Radical SAM Dioldehydratases from Dehydrogenases.” J. Am. Chem. Soc. 2025, 147, 4111-4119. [PMC11826333]
  28. Zhao, H.; Bu, J.; Liu, H.-w. “Radical S-Adenosylmethionine Sulfurtransferase MybB Catalyzed Formation of the 4-Thiazolidinone Core in Mycobacidin Represents an Intersection between Primary and Secondary Metabolism.” J. Am. Chem. Soc. 2025, 147, 4180-4187. [PMC11826332]