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Liu Lab

The University of Texas at Austin College of Pharmacy

2012-2010

  1. Sasaki, E.; Lin, C.-I.; Lin, K.-Y.; Liu, H.-w. “In vitro Characterization of LmbR and LmbN: Construction of the Octose 8-Phosphate Intermediate in Lincomycin A Biosynthesis.” J. Am. Chem. Soc. 2012, 134, 17432-17435.
  2. Huang, H.; Chang, W.-c.; Pai, P.-J.; Romo, A.; Mansoorabadi, S. O.; Russell, D. H.; Liu, H.-w. “Evidence of a Radical-Mediated Mechanism in HppE-catalyzed Oxidation Reaction – A Study of Cyclopropyl and Methylenecyclopropyl Substrate Analogues. ” J. Am. Chem. Soc. 2012, 134, 16171-16174.
  3. Choi, S.-h.; Mansoorabadi, S. O.; Liu, Y.-n.; Chien, T.-C.; Liu, H.-w. “Analysis of UDP-D-Apiose/UDP-D-Xylose Synthase Catalzyed Conversion of UDP-D-Apiose Phosphonate to UDP-D-Xylose Phosphonate: Implications for a Retroaldol-Aldol Mechanism.” J. Am. Chem. Soc. 2012, 134, 13946-13949.
  4. Vasicek, L.; O’Brien, J. P.; Browning, K.; Tao, Z.; Liu, H.-w.; Brodbelt, J. S. “Mapping Protein Surface Accessibility via an Electron Transfer Dissociation Selectively Cleavable Probe.” Mol. Cell. Proteomics. 2012,11, 0111.015826.
  5. Isiorho, E. A.; Liu, H.-w.; Keatinge-Clay, A. “Structural Studies of SpnG: A Glycosyltransferase Involved in Spinosyn Biosynthesis.” Biochemistry 2012, 51, 1213-1222.
  6. Kim, H. J.; Ruszczycky, M. W.; Liu, H.-w. “Current Development and Challenges in the Search of a Naturally Selected Diels-Alderase.” Cur. Opin. Chem. Biol. 2012, 16, 124-131.
  7. Ruszczycky, M. W.; Ogasawara, Y.; Liu, H.-w. “Radical SAM Enzymes in the Biosynthesis of Sugar-Containing Natural Products.” Biochem. Biophys. Acta Proteins & Proteomics, 2012, 1824, 1231-1244.
  8. Sun, H. G.; Ruszczycky, M. W.; Chang, W.-c.; Thibodeaux, C. J.; Liu, H.-w. “Nucleophilic Participation of the Reduced Flavin Cofactor in the Mechanism of UDP-Galactopyranose Mutase.” J. Biol. Chem. 2012, 287, 4602-4608.
  9. Calveras, J.; Thibodeaux, C. J.; Mansoorabadi, S. O.; Liu, H.-w. “Stereochemical Studies of the Type II Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase Implicate the FMN Coenzyme in Protonation of Substrate.” ChemBioChem. 2012, 13, 42-46.
  10. Thibodeaux, C. J.; Chang, W.-c.; Liu, H.-w. “Enzymatic Chemistry of Cyclopropane, Epoxide, and Aziridine Biosynthesis.” Chem. Rev. 2012, 112, 1681-1709.
  11. Chang, W.-c.; Xiao, Y.; Liu, H.-w.; Liu, P. “Mechanistic Studies of IspH-catalyzed Reaction: Elucidation of the Mode of Substrate Binding and Protonation.” Angew. Chem. Int. Ed. 2011, 50, 12304-12307.
  12. Xiao, Y.; Chang, W-.c.; Liu, H.-w.; Liu, P. “An Examination of IspH, A Key Enzyme In the Deoxyxylulose Phosphate Pathway, with Fluorosubstituted Substrate Analogues: Insight into Substrate Binding and Catalysis.” Org. Lett. 2011, 13, 5912-5915.
  13. Choi, S.-h.; Ruszcycky, M. W.; Zhang, H.; Liu, H.-w. “A Fluoro Analogue of UDP-α-D-Glucuronic Acid is an Inhibitor of UDP-α-D-Apiose/UDP-α-D-Xylose Synthase.” Chem. Comm. 2011, 10130-10132.
  14. Yun, D,; Mishtu, D.; Luke, H. J.; Yan, F.; Liu, H.-w.; Drennan, C. L. “Structural Basis of Regiospecificity of a Mononuclear Iron Enzyme in Antibiotic Fosfomycin Biosynthesis.” J. Am. Chem. Soc. 2011, 133, 11262-11269.
  15. Ruszcycky, M. W.; Choi, S.-h.; Mansoorabadi, S. O.; Liu, H.-w. “Mechanistic Studies of the Radical SAM Enzyme DesII: EPR Characterization of a Radical Intermediate Generated During Its Catalyzed Dehydrogenation of TDP-D-Quinovose.” J. Am. Chem. Soc. 2011, 133, 7292-7295.
  16. Kim, H. J.; Ruszczycky, M. W.; Choi, S. H.; Liu, Y.-n.; Liu, H.-w. “An Enzyme-Catalyzed [4+2] Cycloaddition is a Key Step in the Biosynthesis of Spinosyn A.” Nature 2011, 473, 109-112.
  17. Romo, A. J.; Liu, H.-w. “Coenzyme B6-Dependent Enzymes Involved in the Biosynthesis of Deoxy Sugars and Amino Sugars.” Biochem. Biophys. Acta Proteins & Proteomics 2011, 1814, 1534-1547.
  18. Thibodeaux, C. J.; Liu, H.-w. “Mechanism of the Unusual PLP-dependent 1-Aminocyclopropane-1-carboxylic Acid (ACC) Deaminase (ACCD) from Pseudomonas: A Kinetic and Spectroscopic Study.” Biochemistry2011, 50, 1950-1962.
  19. Sasaki, E.; Liu, H.-w. “Mechanism of the Biosynthesis of 2-Thiosugar: Evidence for the Formation of an Enzyme-Bound 2-Ketohexose Intermediate in BexX-Catalyzed Reaction.” J. Am. Chem. Soc. 2010, 132, 15544-15546.
  20. Borisova, S.; Guppi, S. R.; Wu, B.; Kim, H. J.; Liu, H.-w.; O’Doherty, G. A. “A De Novo Approach to the Synthesis of Glycosylated Methymycin Analogues with Structural and Stereochemical Diversity.” Org. Letters2010, 12, 5150-5153.
  21. Borisova, S.; Liu, H.-w. “Characterization of the Glycosyltransferase DesVII and Its Auxiliary Partner Protein DesVIII in the Methymycin/Pikromycin Biosynthetic Pathway.” Biochemistry 2010, 49, 8071-8084.
  22. Zhao, L.; Liu, H.-w. “Pathway and Enzyme Engineering and Applications for Glycodiversification.”In Enzyme Technologies: Metagenomics, Evolution, Biocatalysis and Biosynthesis, (Yeh, W.-K., Yang, H.-C., McCarthy, J. R., Eds.), John Wiley: New York; 2010, 309-362.
  23. Thibodeaux, C. J.; Chang, W.-c.; Liu, H.-w. “Linear Free Energy Relationships Demonstrate a Catalytic Role for the Flavin Mononucleotide Coenzyme of the Type II Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase.” J. Am. Chem. Soc. 2010, 132, 9994-9996.
  24. Sasaki, E.; Ogasawara, Y.; Liu, H.-w. “A Biosynthetic Pathway for BE-7585A: A 2-Thiosugar-containing Augucycline-type Natural Product.” J. Am. Chem. Soc. 2010, 132, 7405-7417.
  25. Kim, H. J.; White-Phillip, J. A.; Ogasawara, Y.; Shin, N.; Isiorho, E. A.; Liu, H.-w. “The Biosynthesis of Spinosyn in Saccharopolyspora spinosa: Synthesis of the Methylated Rhamnose and Characterization of the Functions of SpnH, SpnI, and SpnK.” J. Am. Chem. Soc. 2010, 132, 2901-2903.
  26. Lehwald, P.; Richter, M.; R�hr, C.; Liu, H.-w.; M�ller, M. “Asymmetirc Intermolecular Crossed Aldehyde-Ketone Condensation through Enzymatic Carboligation Reaction.” Angew. Chem. Int. Ed. 2010, 49, 2389-2392.
  27. Ruszczycky, M. W.; Choi, S. H.; Liu, H.-w. “Stoichiometry of the Redox Neutral Deamination and Oxidative Dehydrogenation Reactions Catalyzed by the Radical SAM Enzyme DesII.” J. Am. Chem. Soc. 2010, 132, 2359-2369.

 

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