2000-1998

  1. He, X.; Agnihotri, G.; Liu, H.-w. “Novel Enzymatic Mechanisms in Carbohydrate Metabolism.” Chem. Rev.2000, 100, 4615-4661.
  2. Yamase, H.; Zhao, L.; Liu, H.-w. “Engineering a Hybrid Sugar Biosynthetic Pathway: Production of L-Rhamnose and Its Implication on Dihydrostreptose Biosynthesis.” J. Am. Chem. Soc. 2000, 122, 12397-12398.
  3. Hallis, T. M.; Zhao, Z.; Liu, H.-w. “New Insights into the Mechanism of CDP-D-Tyvelose 2-Epimerase: An Enzyme Catalyzing Epimerization at an Unactivated Stereocenter.” J. Am. Chem. Soc. 2000, 122, 10493-10503.
  4. Kirkpatrick, P. N.; Scaife, W.; Hallis, T. M.; Liu, H.-w.; Spencer, J. B.; Williams, D. H. “Characterisation of a Sugar Epimerase Enzyme Involved in the Biosynthesis of a Vancomycin-group Antibiotic.” J. C. S. Chem. Commun. 2000, 1565-1566.
  5. Zhang, Q.; Liu, H.-w. “Studies of UDP-D-Galactopyranose Mutase from Escherichia coli, An Unusual Role of Reduced FAD in Catalysis.” J. Am. Chem. Soc. 2000, 122, 9065-9070.
  6. Chang, C.-W. T.; Johnson, D. A.; Bandarian, V.; Zhou, H.; LoBrutto, R.; Reed, G. H.; Liu, H.-w. “Characterization of A Unique Coenzyme B6 Radical in the Ascarylose Biosynthetic Pathway.” J. Am. Chem. Soc. 2000, 122, 4239-4240.
  7. Chang, C.-W. T.; Zhao, L.; Yamase, H.; Liu, H.-w. “DesVI: A New Member of the Sugar N,N-dimethyltransferase Family Involved in the Biosynthesis of Desosamine.” Angew Chim. Int. Ed. 2000, 39, 2160-2163 (German version: Ein neues Enzym aus der Familie der Aminozucker-N,N-dimethyltransferasen, Angew. Chem. 2000, 112, 2244-2247).
  8. Zhao, L.; Ahlert, J.; Xue, Y.; Thorson, J. S.; Sherman, D. H.; Liu, H.-w. “Engineering A Methymycin-Calicheamicin Hybrid: Construction of Two New Macrolides Carrying A Designed Sugar Moiety.” J. Am. Chem. Soc. 1999, 121, 9881-9882.
  9. Li, D.; Agnihotri, G.; Dakoji, S.; Oh, E.; Lantz, M.; Liu, H.-w. “The Toxicity of Methylenecyclopropylglycine: Studies of Inhibitory Effects of (Methylenecyclopropyl)formyl-CoA on Enzymes Involved in Fatty Acid Metabolism and the Molecular Basis of Its Inactivation of Enoyl-CoA Hydratases.” J. Am. Chem. Soc. 1999, 121, 9034-9042.
  10. Chen. H.; Agnihotri, G.; Guo, Z.; Que, N. L. S.; Chen, X. H.; Liu, H.-w. “Biosynthesis of Mycarose: Isolation and Characterization of Enzymes Involved in the C-2 Deoxygenation.” J. Am. Chem. Soc. 1999, 121, 8124-8125.
  11. Chen, H.; Yeung, S. M.; Que, N. L. S.; Mller, T.; Schmidt, R. R.; Liu, H.-w. “Expression, Purification, and Characterization of TylB, An Aminotransferase in the Biosynthesis of Mycaminose.” J. Am. Chem. Soc. 1999,121, 7166-7167.
  12. Hallis, T. M.; Liu, H.-w. “Mechanistic Studies of the Biosynthesis of Tyvelose: Purification and Characterization of CDP-D-tyvelose 2-Epimerase.” J. Am. Chem. Soc. 1999, 121, 6765-6766.
  13. Borisova, S. A.; Zhao, L.; Sherman, D. H.; Liu, H.-w. “Biosynthesis of Desosamine: Construction of a New Macrolide Carrying a Genetically Designed Sugar Moiety.” Org. Lett. 1999, 1, 133-136.
  14. Hallis, T. M.; Liu, H.-w. “Learning Nature’s Strategies for Making Deoxy Sugars: Pathways, Mechanisms, and Combinatorial Applications.” Acc. Chem. Res. 1999, 32, 579-588.
  15. Johnson, D. A.; Liu, H.-w. “A Mechanistic Analysis of C-O Bond Cleavage Events with a Comparison to 3,6-Dideoxysugar Formation.” In The Biology-Chemistry Interface: A Tribute to Koji Nakanishi, Cooper, R.; Snyder, J. D., Eds.; Marcel Dekker:New York; 1999, 351-396.
  16. Johnson, D. A.; Liu, H.-w. “Deoxysugars: Occurrence, Genetics, and Mechanism of Biosynthesis.” In Comprehensive Chemistry of Natural Product Chemistry, Barton, D., Nakanishi, K.; Meth-Cohn, O.; Eds.; Elsevier Science: Oxford; 1999, p 311-365.
  17. Murakami, K.; Molitor, E. J.; Liu, H.-w. “An Efficient Synthesis of Unsymmetrical Optical Active Phosphatidyl Glycerol.” J. Org. Chem. 1999, 64, 648-651.
  18. Hallis, T. M.; Liu, H.-w. “Stereospecificity of Hydride Transfer for Catalytically Recycled NAD+ in CDP-D-glucose 4,6-Dehydratase.” Tetrahedron 1998, 54, 15975-15982.
  19. Chen, H.; Guo, Z.; Liu, H.-w. “The Enzyme Catalyzing the Branched-chain Coupling in the Biosynthesis of Yersiniose Is A Thiamine 5’-phosphate Dependent Flavoprotein.” J. Am. Chem. Soc. 1998, 120, 11796-11797.
  20. Xue, Y.; Wilson, D.; Zhao, L.; Liu, H.-w.; Sherman, D. H. “Hydroxylation of Macrolactones YC-17 and Narbomycin is Mediated by the pikC-encoded Cytochrome P450 in Streptomyces venezuelae.Chem. Biol.1998, 5, 661-667.
  21.  Zhao, L.; Que, N. L.S.; Xue, Y.; Sherman, D. H.; Liu, H.-w. “Biosynthesis of Desosamine: Probing the Order of C-4 Deoxygenation Versus C-3 Transamination.” J. Am. Chem. Soc. 1998, 120, 12159-12160.
  22. Xue, Y.; Zhao, L.; Liu, H.-w.; Sherman, D. H. “A Gene Cluster for Macrolide Antibiotic Biosynthesis inStreptomyces venezuelae: Architecture of Metabolic Diversity.” Proc. Natl. Acad. Sci. USA. 1998, 95, 12111-12116.
  23. Zhao, L.; Sherman, D. H.; Liu, H.-w. “Biosynthesis of Desosamine: Construction of a New Methymycin/Neomethymycin Analog By Deletion of a Desosamine Biosynthetic Gene.J. Am. Chem. Soc.1998, 120, 10256-10257.
  24. Chen, H.; Guo, Z.; Liu, H.-w. “Expression, Purification, and Characterization of TylM1, An N,N-dimethyltransferase in the Biosynthesis of Mycaminose.J. Am. Chem. Soc. 1998, 120, 9951-9952.
  25. Chang, C.-w. T.; Chen, X. H.; Liu, H.-w. “CDP-6-deoxy-6,6-difluoro-D-glucose, A Mechanism-Based Inhibitor for CDP-D-glucose 4,6-Dehydratase.J. Am. Chem. Soc. 1998, 120, 9698-9699.
  26. Johnson, D. A.; Liu, H.-w. “Mechanisms and Pathways from Recent Deoxysugar Biosynthesis Research.” Cur. Opin. Chem. Biol. 1998, 2, 642-649.
  27. Zhao, L.; Sherman, D. H.; Liu, H.-w. “Biosynthesis of Desosamine: Molecular Evidence Suggesting β-Glucosylation as a Self-Resistance Mechanism in Methymycin/Neomethymycin Producing Strain,Streptomyces venezuelae.” J. Am. Chem. Soc. 1998, 120, 9374-9375.
  28. Li, K.; Leriche, C.; Liu, H.-w. “Synthesis of β-Difluorine-Containing Amino Acids.Bio. Med. Chem. Lett.1998, 8, 1097-1100.
  29. Hallis, T. M.; Lei, Y., Que, N. L. S., Liu, H.-w. “Mechanistic Studies of the Biosynthesis of Paratose: Purification and Characterization of CDP-paratose Synthase.Biochemistry 1998, 37, 4935-4945.
  30. Li, D.; Zhou, H.-q.; Dakoji, S.; Shin, I.; Oh, E.; Liu, H.-w. “Spiropentylacetyl-CoA, A  Mechanism-based Inactivator of Medium-chain Acyl-CoA Dehydrogenase.J. Am. Chem. Soc. 1998, 120, 2008-2017.
  31. Liu, H.-w. “Coenzyme B6 Dependent Novel Bond Cleavage Reactions.Pure Appl. Chem.  1998, 70, 9-16.