Present-2019

  1. Zhang, J.; Fan, P.-H.; Lin, G.-M.; Chang, W.-C.; Liu, H.-w. “Recent Progress in the Biosynthesis of Carbohydrate-Containing Natural Products.” In Comprehensive Chemistry of Natural Product Chemistry, Liu, H-w.; Begley, T., Eds.; Elsvier: New York;. 2020, in press.
  2. Ren, D.; Ruszczycky, M. W.; Ko, Y.; Wang, S.-A.; Ogasawara, Y.; Kim, M.; Liu, H.-w. “Characterization of the Coformycin Biosynthetic Gene Cluster in Streptomyces kaniharaensis.” Proc. Natl. Aca. Sci. USA. 2020, 175, in press.
  3. Ushimaru, R.; Chen, Z.; Zhao, H.; Fan, P.-h.; Liu, H.-w. “Identification of the Enzymes Mediating the Maturation of the Sery-tRNA Synthetase Inhibitor SB-217452 during the Biosynthesis of Albomycins.” Angew. Chem. Int. Ed. 2019, 59, 3558-3562. [PMC7138408].
  4. Ruszczycky, M. W.; Liu, H.-w. “Measurement of Net Rate Constants from Enzyme Progress Curves without Numerical Curve Fitting.” Biochemistry. 2019, 58, 4950-4956. [PMC6910778].
  5. Ren, D.; Wang, S.-A.; Ko, Y.; Geng, Y.; Ogasawara, Y.; Liu, H.-w. “Identification of the C-Glycoside Synthases during Biosynthesis of the Pyrazole-C-Nucleosides Formycin and Pyrazofurin.” Angew. Chem. Int. Ed. 2019, 58, 16512-16516. [PMC6911263].
  6. Romo, A.; Ikeuchi, H.; Shiraishi, T.; Lin, G.-M.; Geng, Y.; Lee, Y.-H.; Liem, P. H.; Ma, T.; Ogasawara, Y.; Shin-Ya, K.; Nishiyama, M.; Kuzuyama, T.; Liu, H.-w. “Miharamycins and Amipurimycin Biosynthetic Gene Clusters: Unravelling the Origins of 2-Aminopurinyl Peptidyl Nucleoside Antibiotics.” J. Am. Chem. Soc. 2019, 141, 14152-14159. [PMC6774755].
  7. Wang, S.-A.; Ko, Y.; Zheng, J.; Geng, Y.; Ren, D.; Ogasawara, Y.; Irani, S.; Zhang, Y.; Liu, H.-w. “Identification of the Formycin A Biosynthetic Gene Cluster from Streptomyces kaniharaensis Illustrates the Interplay Between Biological Pyrazolopyrimidine Formation and de novo Purine Biosynthesis.” J. Am. Chem. Soc. 2019, 141, 6127-6131. [NIHMSID 1021733]
  8. Pan, H.-X.; Chen, Z.; Zeng, T.; Jin, W.-B.; Geng, Y.; Lin, G.-M.; Zhao, J.; Li, W.-T.; Xiong, Z.; Huang, S.-X.; Zhai, X.; Liu, H.-w.; Tang, G.-L. “Elucidation of the Herbicidin Tailoring Pathway Offers New Insights into Its Structural Diversity.” Org. Lett. 2019, 21, 1374-1378. [NIHMSID1020766]
  9. Ushimaru, R.; Liu, H.-w. “Biosynthetic Origin of the Atypical Stereochemistry in the Thioheptose Core of Albomycin Nucleoside Antibiotics.” J. Am. Chem. Soc. 2019, 141, 2211-2214. [PMC6446896]
  10. Ushimaru, R.; Ruszczycky, M. W.; Liu, H.-w. “Changes in Regiospecificity of H-atom Abstraction During the Hydroxylation and Cyclization Reactions Catalyzed by Hyoscyamine 6β-Hydroxylase.” J. Am. Chem. Soc. 2019, 141, 1062-1066. [NIHMSID 1020764]
  11. Thibodeaux, C. J.; Chang, W.-C.; Liu, H.-w. “Unraveling Flavoenzyme Reaction Mechanisms Using Flavin Analogues and Linear Free Energy Relationships.” Meth. Enzymol. 2019, submitted
  12. Ban, Y. H.; Song, M. C.; Hwang, J.-y.; Shin, H.-l.; Kim, H. J.; Hong, S. K.; Lee, N. J.; Park, J. W.; Cha, S.-S.; Liu, H.-w.; Yoon, Y. J. “Complete Reconstitution of the Diverse Pathways of Gentamicin B Biosynthesis.” Nature Chem. Biol. 2019, 15, 295-303. [NIHMSID 1512665]