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Byung-sun Jeon

Byung-sun JeonDegree: B.S., Seoul National University, Korea
M.S., Seoul National University, Korea

Entered Group: Fall, 2010

Research Projects: Mechanistic Studies of Transannular Cycloaddition Reactions in Natural Product Biosynthesis


Group Publications:

Isiorho, E. A.; Jeon, B.-s.; Kim, N. H.; Liu, H.-w.; Keatinge-Clay, A. T. “Structure Studies of SpnP: A Glycosyltransferase Catalyzing Forosaminylation in Spinosyn Biosynthesis.” Biochemistry 2014, 53, 4292-4301.

Kim, H. J.; Choi, S.-h.; Pongdee, R.; Jeon, B.-s.; Kim, N.; Wu, Q.; Liu, H.-w. “Chemoenzymatic Synthesis of Spinosyn A.” Angew. Chem. Int. Ed. 2014, 53, 13553-13557.

Jeon, B.-s.; Wang, S.-A.; Ruszczycky, M. W.; Liu, H.-w. “Natural [4+2]-Cyclases.” Chem. Review. 2017, 117, 5367-5388.

Jeon, B.-s.; Ruszczycky, M. W.; Russell, W. K.; Lin, G.-M.; Kim, N.; Choi, S.-h.; Wang, S-A.; Liu, Y.-n.; Patrick, J.; Russell, D. H.; Liu, H.-w. “Mechanistic Studies of the SpnF-Catalyzed [4+2]-Cycloaddition in the Biosynthesis of Spinosyn A.” Proc. Natl. Acad. Sci. USA 2017, 114, 10408-10413.

Yang, Z.; Yang, S.; Yu, P.; Li, Y.; Doubleday, C.; Park, J.; Patel, A.; Jeon, B.-s.; Russell, W. K.; Liu, H.-w.; Russell, D. H.; Houk, K. N. “Influence of Water and Enzyme SpnF on the Dynamics and Energetics of the Ambimodal [6+4]/[4+2] Cycloaddition.” Proc. Natl. Acad. Sci. USA 2018, 115, E848-E855.

Choi, S.-h.; Jeon, B.; Kim, N.; Wu, H.-H.; Ko, T.-P.; Ruszczycky, M. W.; Isiorho, E. A.; Liu, Y.-n.; Keatinge-Clay, A. T.; Tsai, M.-D.; Liu, H.-w. “Evidence for an Enzyme Catalyzed Rauhut-Currier Reaction during the Biosynthesis of Spinosyn A.” J. Am. Chem. Soc. 2021, 143, 20291-20295. [PMC8665079]

Joen, B.-s.; Huang, T.-Y.; Ruszczycky, M. W.; Choi, S.-h.; Kim, N.; Franklin, J. L.; Hung, S.-C.; Liu, H.-w. “Byproduct Formation During the Biosynthesis of Spinosyn A and Evidence for an Enzymatic Interplay to Prevent its Formation.” Tetrahedron 2021, in press. [NIHMSID1759956]

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