Shao-An Wang

Shao-An WangDegree: B.S., National Taiwan University

Entered Group: Fall, 2012 (Chemistry program)

Research Projects: Mechanistic Studies of Novel Enzyme Catalysis

Group Publications:

Liu, C.-H.; Wang, S.-A.; Ruszczycky, M. W.; Chen, H.; Li, K.; Murakami, K.; Liu, H.-w. “Studies of 1-Amino-2,2-difluorocyclopropane-1-carboxylate: Mechanism of Decomposition and Inhibition of ACC Deaminase.” Org. Lett. 2015, 17, 3342-3345.

Jeon, B.-s.; Wang, S.-A.; Ruszczycky, M. W.; Liu, H.-w. “Natural [4+2]-Cyclases.” Chem. Review. 2017, 117, 5367-5388.

Ko, Y.; Wang, S.-A.; Ogasawara, Y.; Ruszczycky, M. W.; Liu, H.-w. “Characterization of Enzyme-catalyzed Pyrazolopyrimidine Formation in the Biosynthesis of Formycin A.” Org. Lett. 2017, 19, 1426-1429.

Jeon, B.-s.; Ruszczycky, M. W.; Russell, W. K.; Lin, G.-M.; Kim, N.; Choi, S.-h.; Wang, S-A.; Liu, Y.-n.; Patrick, J.; Russell, D. H.; Liu, H.-w. “Mechanistic Studies of the SpnF-Catalyzed [4+2]-Cycloaddition in the Biosynthesis of Spinosyn A.” Proc. Natl. Acad. Sci. USA 2017, 114, 10408-10413.

Wang, S.-A.; Ko, Y.; Zheng, J.; Geng, Y.; Ren, D.; Ogasawara, Y.; Irani, S.; Zhang, Y.; Liu, H.-w. “Identification of the Formycin A Biosynthetic Gene Cluster from Streptomyces kaniharaensis Illustrates the Interplay Between Biological Pyrazolopyrimidine Formation and de novo Purine Biosynthesis.” J. Am. Chem. Soc. 2019, 141, 6127-6131. [NIHMSID 1021733]

Ren, D.; Wang, S.-A.; Ko, Y.; Geng, Y.; Ogasawara, Y.; Liu, H.-w. “Identification of the C-Glycoside Synthases during Biosynthesis of the Pyrazole-C-Nucleosides Formycin and Pyrazofurin.” Angew. Chem. Int. Ed. 2019, 58, 16512-16516. [PMC6911263]

Ren, D.; Ruszczycky, M. W.; Ko, Y.; Wang, S.-A.; Ogasawara, Y.; Kim, M.; Liu, H.-w. “Characterization of the Coformycin Biosynthetic Gene Cluster in Streptomyces kaniharaensis.” Proc. Natl. Aca. Sci. USA. 2020, 117, 10265-10270. [PMC7229688]

Wang, S.-A.; Lin, C.-I.; Zhang, J.; Ushimaru, R.; Sasaki, E.; Liu, H.-w. “Studies of Lincosamide Formation Complete the Biosynthetic Pathway for Lincomycin A.” Proc. Natl. Acad. Sci. USA 2020, 117, 24794-24801.