Yeonjin Ko

Yeonjin KoDegree: B.S., Seoul National University, Korea
M.S., Seoul National University, Korea

Entered Group: Fall, 2010

Research Projects: Development of Cancer Vaccines, Biosynthetic Studies of Novel Secondary Metabolites

Group Publications:

Ko, Y.; Ruszczycky, M. W.; Liu, H.-w. “Mechanistic Studies of the Radical SAM Enzyme DesII with TDP-D-fucose.” Angew. Chem. Int. Ed. 2015, 54, 860-863.

Ko, Y.; Wang, S.-A.; Ogasawara, Y.; Ruszczycky, M. W.; Liu, H.-w. “Characterization of Enzyme-catalyzed Pyrazolopyrimidine Formation in the Biosynthesis of Formycin A.” Org. Lett. 2017, 19, 1426-1429.

Ko, Y.; Lin, G.-M.; Ruszczycky, M. W.; Liu, H.-w. “Mechanistic Implications of the Deamination of TDP-4-amino-4-deoxy-fucose Catalyzed by the Radical SAM Enzyme DesII.” Biochemistry 2018, 57, 3130-3133.

Wang, S.-A.; Ko, Y.; Zheng, J.; Geng, Y.; Ren, D.; Ogasawara, Y.; Irani, S.; Zhang, Y.; Liu, H.-w. “Identification of the Formycin A Biosynthetic Gene Cluster from Streptomyces kaniharaensis Illustrates the Interplay Between Biological Pyrazolopyrimidine Formation and de novo Purine Biosynthesis.” J. Am. Chem. Soc. 2019, 141, 6127-6131. [NIHMSID 1021733]

Ren, D.; Wang, S.-A.; Ko, Y.; Geng, Y.; Ogasawara, Y.; Liu, H.-w. “Identification of the C-Glycoside Synthases during Biosynthesis of the Pyrazole-C-Nucleosides Formycin and Pyrazofurin.” Angew. Chem. Int. Ed. 2019, 58, 16512-16516. [PMC6911263]

Ren, D.; Ruszczycky, M. W.; Ko, Y.; Wang, S.-A.; Ogasawara, Y.; Kim, M.; Liu, H.-w. “Characterization of the Coformycin Biosynthetic Gene Cluster in Streptomyces kaniharaensis.” Proc. Natl. Aca. Sci. USA. 2020, 117, 10265-10270. [PMC7229688]