Houyuan Zhao Degree: B.S., Wuhan University, China Entered Group: Fall, 2018 (Chemistry program) Research Projects: Radical SAM enzymology, biosynthesis of albomycins Group Publications: Zhao, H.; Bu, J.; Liu, H.-w. “Characterization of an Unusual Suicide Radical AdoMet Enzyme MybB Catalyzing Sulfur Incorporation into the Biosynthesis of Antitubercular Mycobacidin.” Meth. Enzymol. in press. Zhao, H.; Liu, H.-w. “A Novel Amidation Reaction Couples the Siderophore Bait with the SB-217452 Warhead to Complete the Biosynthesis of the Trojan-horse Antibiotic Albomycin δ2.” J. Am. Chem. Soc. 2026, 148, 21797-21806. Zhao, H.; Chen, Z.; Franklin, J. L.; Liu, H.-w. “Characterization of C3′ Epimerization of the Thioheptose Core in the Biosynthesis of Albomycin δ2 Catalyzed by the Radical S-Adenosylmethionine Enzyme AbmJ.” ACS Catal. 2025, 15, 18104-18111. Zhao, H.; Bu, J.; Liu, H.-w. “Radical S-Adenosylmethionine Sulfurtransferase MybB Catalyzed Formation of the 4-Thiazolidinone Core in Mycobacidin Represents an Intersection between Primary and Secondary Metabolism.” J. Am. Chem. Soc. 2025, 147, 4180-4187. [PMC11826332] Ushimaru, R.; Chen, Z.; Zhao, H.; Fan, P.-h.; Liu, H.-w. “Identification of the Enzymes Mediating the Maturation of the Sery-tRNA Synthetase Inhibitor SB-217452 during the Biosynthesis of Albomycins.” Angew. Chem. Int. Ed. 2019, 59, 3558-3562. [PMC7138408]
