Hak Joong Kim

Hak Joong KimDegree: B.S., Seoul National University, Korea
M.S., Seoul National University, Korea

Entered Group: Spring, 2010

Research Projects: Mechanistic Studies of the Biosynthesis of Novel Secondary Metabolites

Group Publications:

Kim, H. J.; McCarty, R. M.; Ogasawara, Y.; Mansoorabadi, S. O.; Liu, Y.-n.; Levieux, J.; Liu, H.-w. “The GenK-catalyzed C-6′ Methylation in the Biosynthesis of Gentamicin: Isolation and Characterization of a Cobalamin-dependent Radical SAM Enzyme.” J. Am. Chem. Soc. 2013, 135, 8093-8096.

Kim, H. J.; Choi, S.-h.; Pongdee, R.; Jeon, B.-s.; Kim, N.; Wu, Q.; Liu, H.-w. “Chemoenzymatic Synthesis of Spinosyn A.” Angew. Chem. Int. Ed. 2014, 53, 13553-13557.

Kim, H. J.; LeVieux, J.; Yeh, Y.-C.; Liu, H.-w. “C3′-Deoxygenation of Paromamine Catalyzed by a Radical SAM Enzyme: Characterization of AprD4 and Its Reductase Partner AprD3.” Angew. Chem. Int. Ed. 2016, 55, 3724-3728.

Kim, H. J.; Liu, Y.-n.; McCarty, R. M.; Liu, H.-w. “Biochemical Characterization and Stereochemical Analysis of Reactions Catalyzed by GenK, a Cobalamin-Dependent Radical SAM Methyltransferase Involved in Gentamicin Biosynthesis.” J. Am. Chem. Soc. 2017, 139, 16084-16087.

Ban, Y. H.; Song, M. C.; Hwang, J.-y.; Shin, H.-l.; Kim, H. J.; Hong, S. K.; Lee, N. J.; Park, J. W.; Cha, S.-S.; Liu, H.-w.; Yoon, Y. J. “Complete Reconstitution of the Diverse Pathways of Gentamicin B Biosynthesis.” Nature Chem. Biol. 2019, 15, 295-303.