Richiro Ushimaru

ushimaruDegree: B.S., Nagoya University, Japan

Entered Group: August, 2013 (Chemistry program)

Research Projects: Mechanistic Studies of the Biosynthesis of Secondary Metabolites

Group Publications:

Ushimaru, R.; Lin, C.-I.; Sasaki, E.; Liu, H.-w. “Characterization of Enzymes Catalyzing Transformations of Cysteine S-Conjugated Intermediates in the Lincosamide Biosynthesis Pathway.” ChemBioChem 2016, 17, 1606-1611.

Ushimaru, R.; Ruszczycky, M. W.; Chang, W.-C.; Yan, F.; Liu, Y.-n.; Liu, H.-w. “Substrate Conformation Correlates with the Outcome of Hyoscyamine 6β-Hydroxylase Catalyzed Oxidation Reactions.” J. Am. Chem. Soc. 2018, 140, 7433-7436.

Ushimaru, R.; Ruszczycky, M. W.; Liu, H.-w. “Changes in Regiospecificity of H-atom Abstraction During the Hydroxylation and Cyclization Reactions Catalyzed by Hyoscyamine 6β-Hydroxylase.” J. Am. Chem. Soc. 2019, 141, 1062-1066.

Ushimaru, R.; Liu, H.-w. “Biosynthetic Origin of the Atypical Stereochemistry in the Thioheptose Core of Albomycin Nucleoside Antibiotics.” J. Am. Chem. Soc. 2019, 141, 2211-2214.

Ushimaru, R.; Chen, Z.; Zhao, H.; Fan, P.-h.; Liu, H.-w. “Identification of the Enzymes Mediating the Maturation of the Sery-tRNA Synthetase Inhibitor SB-217452 during the Biosynthesis of Albomycins.” Angew. Chem. Int. Ed. 2019, 59, 3558-3562. [PMC7138408]

Wang, S.-A.; Lin, C.-I.; Zhang, J.; Ushimaru, R.; Sasaki, E.; Liu, H.-w. “Studies of Lincosamide Formation Complete the Biosynthetic Pathway for Lincomycin A.” Proc. Natl. Acad. Sci. USA 2020, 117, 24794-24801.